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                      Baking Soda Improves Cancer Treatment?

                      Published by Life Extension

                      baking soda
                      Consuming baking soda may help immunotherapy drugs to fight difficult-to-treat tumors. This cheap and simple intervention may eventually improve current cancer treatments.

                      Baking soda could help to boost immunotherapy.

                      Within tumors, large portions are deprived of oxygen. Scientists know that these hypoxic regions tend to be the most resistant to treatment.

                      If a cell is unable to access adequate oxygen, it slows down and enters what is known as a quiescent state.

                      The molecular switch mTORC1 is responsible for assessing the situation before telling the cell whether or not it should divide.

                      If mTORC1 is not present, the cell’s internal processes are shut down. Deep within tumours, mTORC1 activity is almost non-existent.

                      New research delves deeper into this mechanism and finds an incredibly simple way to reverse it: baking soda.

                      The study took place at the Wistar Institute and the University of Pennsylvania, both of which are located in Philadelphia. The scientists published their results this week in the journal Cell.

                      Lysosomes, the minuscule bags of enzymes that break down proteins and other biomolecules, were found to play a key role.

                      The lysosomes of interest are usually situated next to the nucleus. However, when conditions are more acidic – which develops during hypoxia – protein motors transport lysosomes carrying mTOR to other locations.

                      This movement of mTOR away from the nucleus also transports it away from a protein called RHEB, which is essential for it to function. Without its primary activator, mTOR activity is reduced, the cell’s processes slow down, and most metabolic activity stops.

                      The study was led by Chi Van Dang, and he explains why this occurs, saying, “Cells don’t want to make proteins or other biomolecules when they’re under stress. They want to slow things down and only awaken when things return to normal.”

                      When a cell enters this quiescent state, cancer drugs are much less effective. So, the researchers wanted to see if it could be overturned. They found that, when mice were given baking soda in their drinking water, the acidity of the quiescent regions of tumors was reversed.

                      Once this had occurred, lysosomes were sent back toward the nucleus, mTOR was activated by RHEB, and cellular processes were switched back on.

                      Dang explains what the scientists saw after mice had consumed baking soda, saying, “[T]he entire tumor lights up with mTOR activity. The prediction would be that by reawakening these cells, you could make the tumor far more sensitive to therapy.”

                      “The concept is so easy. It’s not some $100,000 per year drug. It’s literally just baking soda.”

                      Cancer immunotherapy has been demonstrated to be less effective in acidic conditions because T cell activation is reduced, so this finding could have important ramifications.

                      Acidity’s role in cancer progression and treatment is a fledgling area of research, which means that much more work will surely follow. Dang and his team plan to continue their experimentation, focusing on how acidity impacts immunotherapy.

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension. https://www.lifeextension.com/

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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