August 7, 2018
On July 2, 2018, The Journal of Neuroscience reported the discovery of an ability of aspirin to decrease amyloid beta plaque in a mouse model of Alzheimer’s disease. The presence in the brain of amyloid beta plaques, along with neurofibrillary tangles made up of hyperphosphorylated tau protein, are among the characteristics of Alzheimer’s disease in humans. Dr Pahan and colleagues determined that aspirin upregulates transcription factor EB (TFEB), a regulator of lysosome formation. “Lysosomes play a central role in cellular homeostasis by regulating the cellular degradative machinery,” lead researcher Kalipada Pahan, PhD, and colleagues explain. “Since aberrant lysosomal function has been associated with […]