An article appearing August 21, 2017 in Nature Medicine reveals a potential role for senolytic compounds, including quercetin and the drug dasatinib, in the targeting of senescent cells to help maintain bone. “While we know from previous work that the accumulation of senescent cells causes tissue dysfunction, the role of cell senescence in osteoporosis up to this point has been unclear,” noted researcher Sundeep Khosla, MD, of the Mayo Clinic’s Robert and Arlene Kogod Center on Aging. “The novelty of this work for the bone field lies in the fact that, rather than targeting a bone-specific pathway, as is the case for all current […]