Study Data from State University of Campinas Provide New Insights into Tendinitis (Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon)
By a News Reporter-Staff News Editor at Health & Medicine Week — Investigators publish new report on Tendinitis. According to news reporting from Sao Paulo, Brazil, by NewsRx journalists, research stated, “The myotendinous junction (MTJ) is the weakest element in the muscle-tendon unit of the heel, and thus the most susceptible to injuries. The scarcity of adequate treatments means that tendinitis is a major concern to athletes and other groups who depend on their physical fitness, although green tea and glycine have both been shown to have beneficial effects on the inflammation.”
The news correspondents obtained a quote from the research from the State University of Campinas, “The present study investigated the remodeling effects of green tea and glycine in the MTJ of rats with tendinitis. For this, male Wistar rats were divided into five groups: animals without tendinitis and animals with tendinitis; animals with tendinitis supplied with green tea; animals with tendinitis supplied with a glycine diet; animals with tendinitis supplied with a green tea and glycine diet. Tendinitis was induced and the treatment with green tea (700 mg/kg/day) and a 5% glycine diet lasted 7 days. The treatments regulated the activity of metalloproteinases (MMP)-2, -8, and -9, and induced the synthesis of type I collagen, glycosaminoglycans, and non-collagenous proteins. Changes were also noted in the compaction of the collagen molecules and the amount of tenocytes. When combined, green tea and glycine modulated the inflammatory process and induced the synthesis of the elements involved in the post-lesion recovery of the tissue. The data from the MTJ were different when compared with results already published using the whole Achilles tendon.”
According to the news reporters, the research concluded: “These data indicate that each region of the inflamed tendon can exhibit different responses during the treatment and therefore, modify its extracellular matrix components to facilitate recovery and repair.”
For more information on this research see: Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 2016;299(7):918-928. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA (see also Tendinitis).
Our news journalists report that additional information may be obtained by contacting State University, Dept. of Pharmacol, BR-13083863 Sao Paulo, Brazil. Additional authors for this research include L.P. De Oliveira, F.D. Guerra,M.C.C. Marcondes and E.R. Pimentel.
Keywords for this news article include: Sao Paulo, Brazil, South America, Extracellular Matrix Proteins, Tendinopathy, Amino Acids, Tendinitis, Collagen, Glycine, State University of Campinas.