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                      Exercise Hormone May Protect Against Alzheimer’s

                      Published by Life Extension

                      Close up look on retired women lunging at fitness club

                      A hormone released during exercise may protect the brain against Alzheimer’s disease, research suggests.

                      Irisin is a messenger protein generated by muscle tissue that is carried around the body in the bloodstream.

                      The new evidence indicates that it may be behind the known positive effects on mental performance of taking exercise.

                      US and Brazilian scientists found lower levels of the hormone in the brains of Alzheimer’s patients compared with healthy individuals. The same was true for the precursor protein from which irisin is derived, FNDC5.

                      In tests on genetically engineered mice, the scientists induced learning and memory deficits by cutting out irisin.

                      They were able to reverse these effects by restoring the hormone.

                      When irisin signalling was blocked in mice with a rodent version of Alzheimer’s, the brain benefits of physical exercise were lost.

                      The research, led by Dr Fernana de Felice, from the Federal University of Rio de Janerio in Brazil, is reported in the journal Nature Medicine.

                      Bolstering irisin, either with drugs or through exercise, could provide a “novel strategy” for preventing cognitive decline in patients with Alzheimer’s disease, said the scientists.

                      They wrote: “Our results demonstrate that FNDC5/irisin levels are reduced in human AD (Alzheimer’s disease) brains and cerebrospinal fluid and in AD mouse models, and that boosting either brain or peripheral FNDC5/irisin levels attenuates synaptic and memory impairments in AD mouse models.”

                      Further research was needed to understand exactly how irisin enters the brain and interacts with it, the team added.

                      Dr Rosa Sancho, from the charity Alzheimer’s Research UK, said: “We know that physical activity is linked to better brain health as we age, and this research highlights a biological mechanism that may contribute to this beneficial effect. These interesting findings present a new avenue for future research that could help us better understand how exercise programmes could be targeted to provide the greatest benefit to brain health.

                      “There are many people either with dementia or at high risk of dementia, who have health conditions that make regular exercise more difficult.

                      “Drugs designed to target the hormone identified in this research could potentially bring some of the benefits of physical activity to people who may be less able to exercise.”

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension. https://www.lifeextension.com/

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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